xTAG(R) GPP Now Available Through Accu Reference Medical Lab
Accu Reference Medical Lab adds a Luminex xTAG® Gastrointestinal Pathogen Panel (GPP) to its lineup of highly sensitive, rapid response diagnostic test.
- (1888PressRelease) June 15, 2017 - New Jersey - Gastrointestinal (GI) pathogen panels are used to simultaneously test for the presence of multiple disease-causing (pathogenic) viruses, bacteria, and/or parasites in a stool sample and help diagnose an infection of the digestive system (GI tract). Since there are many causes of GI infections, a GI pathogen panel may be used in conjunction with other tests, such as a stool culture or an ova and parasite exam (O&P), to help establish a diagnosis (1).
The following pathogen types, subtypes, and toxin genes are identified using the xTAG GPP:
- Campylobacter (C. jejuni, C. coli and C. lari only)
- Clostridium difficile (C. difficile) toxin A/B
- Cryptosporidium (C. parvum and C. hominis only)
- Escherichia coli (E. coli) O157
- Enterotoxigenic E. coli (ETEC) LT/ST
- Giardia (G. lamblia only, also known as G. intestinalis and G. duodenalis)
- Norovirus GI/GII
- Rotavirus A
- Salmonella
- Shiga-like Toxin producing E. coli (STEC) stx 1/stx 2
- Shigella (S. boydii, S. sonnei, S. flexneri and S. dysenteriae)
“Same Day Results for 14 of the Most Common Causes of Infectious Diarrhea.”
Diarrhea disease strikes more than two billion times globally each year and is a leading cause of child morbidity and mortality worldwide. 80% of pathogens are not identified, which leads to improper use of antibiotics and poor patient care. In the United States alone, 99 million cases of GI infection occur annually, leading to over 250,000 hospitalizations and 17,000 deaths, inflicting a significant toll on the healthcare system (2-4).
Diarrhea can be caused by wide range of bacterial, viral, and/or parasitic pathogens. Conventional culture based diagnosis has many issues including highly variable, insensitive, labor-intensive and 1 day turnaround time for final results. Recently, multiplex real-time PCR-based diagnosis has been highlighted because of many advantages such as simultaneous detection of a wide range of GI pathogens, fast turnaround time and high reproducibility combined with automatic platforms.
By testing for greater than 90% of the causative pathogens of infectious gastroenteritis in a single test, clinicians can more quickly identify and treat the causative agent. Additionally, co-infections can be more easily identified.
This panel will replace traditional stool culture (STOCU) and the Giardia and Cryptosporidium antigen (OVPSC) screen.
USING GPP IN YOUR CLINICAL PRACTICE
Test Overview
• FDA clears Luminex gastrointestinal pathogen panel (5)
• Non-invasive stool test
• Outstanding accuracy
• Helps decrease and contain outbreaks of highly contagious gastrointestinal infections
• Turn-around time of just 24 hours!
• Helps reduce over-prescription of antibiotics
• Provide better patient care
• Patients return specimens to the lab directly via FedEX
• Widely covered by major insurances
When should the testing be ordered?
• Persistent or chronic diarrhea
• Bloody diarrhea
• Diarrhea in association with systemic illness
• Immunocompromised status
• Returned Traveler
• Hospitalized patient
• Outbreak identification
In healthcare settings and in specific populations (newborns/infants, elderly or immunocompromised patients), these infections are potentially serious. Rapid diagnosis is important for appropriate treatment.
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