AnaSpec Expands HCV NS3/4A Protease Selection
AnaSpec, Eurogentec Group is pleased to announce the expansion of our NS3/4A protease selection to include proteases from genotypes 1a, 1b, 2a, 3a and 4d. These recombinant HCV NS3/4A proteases are highly active and can be used with the SensoLyte® 490, 520, or 620 HCV Protease Assay Kits for screening of anti-HCV protease drugs.
- (1888PressRelease) December 10, 2010 - HCV NS3 protease is responsible for the cleavage at the NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites of the nonstructural protein. It is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy.3-7
Hepatitis C Virus (HCV) belongs to the Flaviviridae family of positive, single stranded RNA. Approximately 170 million people worldwide are infected with this virus and infection results in liver diseases such as chronic hepatitis, cirrhosis and hepatocellular carcinoma.1 Seven major HCV genotypes have been identified which differ in >30 nucleotide sites.2 Genotypes 1, 2 and 3 are found predominantly in the US, Europe, Australia, Japan, Taiwan, Thailand and China; Genotype 4 in the Middle East, Egypt and Central Africa; Genotype 5 in South Africa and Genotype 6 in Southeast Asia.2
AnaSpec also provides HCV NS3/4A mutant proteases. These mutants provide researchers with additional tools to assess the implications and explore a response to the emergence of protease inhibitor resistant NS3 proteases.
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Reference
1. Seeff, LB and JH. Hoofnagle, Hepatology 36, S1 (2002).
2. Imhof, I. and P. Simmonds, J. Virol. 84, 4597 (2010).
3. Sali, DL. et al., Biochem. 37, 3392 (1998).
4. Steinkuhler, C. et al., Biochem. 37, 8899 (1998).
5. Gallinari, P. et al., J. Virol. 72, 6758 (1998).
6. Hardy, RW. et al. J. Virol. 77, 2029 (2003).
7. Hamill, P. and F. Jean, Biochem. 44, 6586 (2005).
About AnaSpec
AnaSpec, Inc. is a leading provider of integrated proteomics and genomics solutions™ for worldwide life science research. As a subsidiary of Eurogentec, AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development and oligonucleotide synthesis.
For more information visit www.anaspec.com
About Eurogentec
Eurogentec is a leading global supplier of innovative reagents, kits, specialty products and custom services to scientists in the life science, biotechnology, pharmaceutical and diagnostic markets. Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications. Our ISO13485:2003-certified manufacturing facilities in Belgium provides a wide range of high value oligonucleotide-based components for diagnostic and therapeutic applications. Eurogentec's Belgium manufacturing facility is complemented by additional production facilities in North America and Japan. Eurogentec is also an experienced Contract Manufacturing Organization (CMO) for Biopharmaceuticals, operating a full-service, state-of-the-art GMP facility in Belgium.
Eurogentec is a privately held company headquartered in Liège, Belgium, with subsidiaries in North America, France, Germany, the UK, the Netherlands and Switzerland and has additional production facilities in North America, Japan and Singapore. Eurogentec employs 400+ people globally.
For more information visit www.eurogentec.com
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